Spravato

What is Spravato?

SPRAVATO® is the first FDA-approved nasal spray medication, taken with an oral antidepressant, for treatment-resistant depression in adults.

If you’ve tried two or more antidepressants* without sufficient relief, talk to your healthcare provider to see if you may have treatment-resistant depression. SPRAVATO® is not for use in children and individuals who are pregnant or planning to become pregnant.

How does Spravato work?

• Spravato is administered as a nasal spray
• Upon nasal administration, it is rapidly absorbed into the bloodstream and reaches the brain.
• Spravato targets the N-methyl-Daspartate (NMDA) receptors, leading to an increase in glutamate levels.
• This process is believed to help restore synaptic connections between neurons and reverse the effects of depression.
• Spravato is believed to work differently than currently available oral antidepressants.
• Spravato is taken with an oral antidepressant.

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Treatment Plan

• You will not be able to drive, so plan transportation for treatment days.
• You will administer the nasal spray yourself under the supervision of a healthcare provider.
• You’ll be monitored for side effects for at least two hours.
• Your healthcare provider will tell you when it’s okay to leave.
• Do not drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.

Please click here to download Spravato Treatment Plan.

SPRAVATO® (esketamine) | Official Patient Website

Side effects of Spravato

• Dissociation • Dizziness • Nausea • Feeling sleepy • Spinning sensation • Numbness • Feeling anxious• Lack of energy • Increased blood pressure • Vomiting • Feeling drunk • Feeling very happy or excited

If these common side effects occur, they usually happen right after taking SPRAVATO® and go away the same day.

SPRAVATO® may cause serious side effects including:

• Feeling sleepy (sedation) • Feeling disconnected from yourself, your thoughts, feelings and things around you (dissociation) • Abuse and misuse • Increased risk of suicidal thoughts and behavior • Temporary increase in blood pressure that may last about four hours after a dose • Problems with thinking clearly • Bladder problems

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